Active hemoglobin with highest ability to transport oxygen for application in laboratory reagents (cell culture), cosmetics, medical devices, wound healing and pharmaceuticals

An Austrian SME is developing a novel hemoglobin complex for use in various in-vitro & in-vivo application areas. This complex is characterized by a high oxygen carrying capacity, purity, safety and functionality. The developers are looking for partners who need specific oxygen carriers or want to adopt the technology in their manufacturing environment -technical cooperation, commercial or license agreement are sought.
The product is a novel hemoglobin complex for use as an oxygen carrier in the human blood originally developed by a leading German research institute. At present a consortium of an Austrian and a German small scale enterprise owns the technology and is further developing the hemoglobin complex. Both companies are specialized in the worldwide sourcing and development of biological raw materials. 1) State of the art: Hemoglobin is an iron-containing oxygen-transport metalloprotein in the red blood cells of all vertebrates which carries oxygen from the lungs to the rest of the body. Hemoglobin as an oxygen carrier is therefore essential to preserve organic tissue in various biotechnological and medical applications on living organisms (in vivo) and in test tubes (in vitro). Hemoglobin derived from human blood donations is a rare commodity and not available in sufficient amount. However, hemoglobin can also be isolated from an abundant and low cost source – bovine blood. There are many commercially available bovine hemoglobins but none is acceptable with regard to purity, safety or functionality. Commercially available hemoglobins exhibit a high content (50-100 %) of oxidized hemoglobin (methemoglobin), which is not able to effectively transport oxygen. For this reason the currently available hemoglobin products cannot be used in applications or as a starting material for products that depend on the oxygen carrying capacity of hemoglobin. The market needs a new type of hemoglobin suitable to work as a potent oxygen carrier. 2) Description of the technology: The active hemoglobin complex is manufactured from calves red blood cells sourced in Tyrol, Austria - a region free of most notifiable bovine diseases as well as BSE (Bovine Spongiform Encephalopathy). It has been harvested from locally and organically raised animals with proven traceability and carefully monitored health records. The red blood cells are lysed and the hemoglobin is then obtained via centrifugation and filtration steps. Several virus inactivation methods can be applied as required. The technology is transferable to any geographical region and can be adapted to the specific manufacturing environment. 3) Application Areas: The product was originally developed for the manufacturing of multi-hemoglobin complexes with advantageous properties. Besides the application as an oxygen carrier in the human body, it can be used in many more areas such as: - Human erythrocytes replacement in perfusion media - Active ingredient in wound bandages or wound healing creams / gels (especially for chronic wounds) - Universal cell culture additive for better oxygenation, growth and performance – suitable for all cell types - Ingredient/stabilizer for 3D hydrogels to improve 3D cell culture growth and oxygenation - Ingredient for biological coating of cell culture plastics - Regenerative medicine applications - contributing to joints healing and for a better cartilage recovery - Cosmetic applications like combatting hair loss, preventing cellulite, skin improvement - In any other areas where an improved oxygen supply is required The application research and development of the manufacturing technology has been funded by the European program EUROSTARS. An industrial production scale-up is currently under development. 4) Partner sought: The developers are looking for companies and/or research organizations who need specific oxygen carriers or are interested in adopting the specific technology in their manufacturing environment – in the form of a technical cooperation, commercial or license agreements.
Type (e.g. company, R&D institution…), field of industry and Role of Partner Sought: 
Type of partnership • Commercial agreement with technical assistance • License agreement • Technical cooperation agreement Type and role of Partner sought 1) Type of partner sought: - Researchers - Cell culture users - Cell culture manufacturers - Pharma companies - In-vitro diagnostic manufacturers - Manufacturers of medicinal products - Manufacturers of medical devices - Cosmetics manufacturers (special focus on personalized cosmetics) - Distributors in the medical sector 2) Role of partner sought: The developers would like to get in contact with manufacturers and industrial researchers working with oxygen carriers. They are open to out-license the manufacturing technology through a license agreement and also to make final adaptations to the product for specific market requirements through a technical cooperation agreement. Partners interested in a commercial or license agreement will receive the expertise and also the technical and regulatory assistance for the adaptation process of the technology to their specific environment. Samples can be provided in order to test the oxygen carrier for the specific application of the interested party.
Stage of Development: 
Available for demonstration
Comments Regarding Stage of Development: 
First commercial products (cell culture supplements, hydrogels, particles) under development, samples and prototypes available for testing Application for use with human tissue is not yet certified.
IPR Status: 
Granted patent or patent application essential
Comments Regarding IPR Status: 
Several worldwide patents have been granted
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