Investigations of physico-chemical properties in solid compounds

Technological properties like shelf-life, compacting, hygroscopicity, electrostatic charging, solubility and many more can be improved by a deeper knowledge of solid-state chemistry and crystallography of products. A German university spin-off offers special expertise in screening techniques for crystallization of cocrystals, polymorphs or salts from active pharmaceutical ingredients and/or amorphous materials In collaboration with experts in trace and micro analyses the company can accurately identify and, even more important, quantify the active ingredients and excipients in drug products. The solid-state form is likewise important to precisely describe the complex mixtures under investigation using the company's own reference data, comparing them with a vast number of polymorphs and pseudopolymorphs. Particle identification is crucial for many applications, particle size measured by scattering methods, membrane (core pore) filtration and imaging by macro- and micrographs, and several spectroscopic methods are able to evaluate fundamental information in research, development and manufacturing. There exists an unbelievable complexity in solid-chem variation of one chemical compound resulting in various entities: polymorphs, salts, cocrystals, solvates, hydrates, solid solutions and mixed crystals up to a variety in the state of amorphous materials. They can be produced, modified, identified and distinguished which is necessary for any application. The approach to the new entities can be realized by rational design, (micro) screening, in silico-screening (computational predictions) and intermediates thereof. The German University spin-off has special know-how and expertise, among others in European projects. They are looking for partners from the field of pharma, food and chemical industry who require discovery-to-development transition of research projects. Industrial partners are sought for technological and/or research cooperation agreement.