Chimeric antigen receptors (CARs) have been developed for the molecular engineering of effector T-cells to be used in targeted cancer therapy. CARs consist of the antigen-binding single-chain fragment (scFv) of an antibody fused via a hinge region to a transmembrane domain (TM) and to one or more intracellular signalling co-stimulatory regions. CAR expressing T-cells are now able to specifically (and in a major histocompability complex-independent manner) recognize the corresponding tumor-associated antigens. The different scFv-regions determine the specifity and affinity of the CARs.

Founded in 1996, the Berlin-based German company produces audio-visual content (20-25 new productions per year), primarily for primetime slots at German public TV stations. Hereby, the focus is on creative documentaries and media packages with an international background, regarding topics like history, politics, science and nature. Two films per year are produced for cinemas while the others are TV documentaries. About three third of the film productions are produced for international licensing and reach a market in up to 55 countries worldwide.